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Childhood malignant neoplasm

MedGen UID:
82962
Concept ID:
C0278704
Neoplastic Process
Synonyms: Childhood Cancer; childhood cancer; Childhood Malignant Neoplasm; childhood malignant neoplasm; childhood neoplasm, malignant; Malignant Childhood Neoplasm; malignant childhood neoplasm; Malignant Childhood Tumor; malignant childhood tumor; malignant childhood tumour; malignant paediatric neoplasm; malignant paediatric tumour; Malignant Pediatric Neoplasm; malignant pediatric neoplasm; Malignant Pediatric Tumor; malignant pediatric tumor; paediatric cancer; Pediatric Cancer; pediatric cancer
 
Monarch Initiative: MONDO:0006517

Definition

A malignant neoplasm that occurs during childhood. Representative examples include acute leukemias, malignant brain neoplasms, and sarcomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood malignant neoplasm

Professional guidelines

PubMed

Yamamoto H, Sakamoto H, Kumagai H, Abe T, Ishiguro S, Uchida K, Kawasaki Y, Saida Y, Sano Y, Takeuchi Y, Tajika M, Nakajima T, Banno K, Funasaka Y, Hori S, Yamaguchi T, Yoshida T, Ishikawa H, Iwama T, Okazaki Y, Saito Y, Matsuura N, Mutoh M, Tomita N, Akiyama T, Yamamoto T, Ishida H, Nakayama Y
Digestion 2023;104(5):335-347. Epub 2023 Apr 13 doi: 10.1159/000529799. PMID: 37054692
Stockklausner C, Duffert CM, Cario H, Knöfler R, Streif W, Kulozik AE; THROMKID-Plus Studiengruppe der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) and of Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH)
Ann Hematol 2021 Jul;100(7):1647-1665. Epub 2021 Mar 12 doi: 10.1007/s00277-021-04485-0. PMID: 33712866Free PMC Article
Miller DT, Freedenberg D, Schorry E, Ullrich NJ, Viskochil D, Korf BR; COUNCIL ON GENETICS; AMERICAN COLLEGE OF MEDICAL GENETICS AND GENOMICS
Pediatrics 2019 May;143(5) doi: 10.1542/peds.2019-0660. PMID: 31010905

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Recent clinical studies

Etiology

Ranganathan S, Lopez-Terrada D, Alaggio R
Pediatr Dev Pathol 2020 Mar-Apr;23(2):79-95. Epub 2019 Sep 25 doi: 10.1177/1093526619875228. PMID: 31554479
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Olsen ØE
Pediatr Radiol 2015 Jan;45(1):35-41. Epub 2015 Jan 1 doi: 10.1007/s00247-014-3148-0. PMID: 25552390Free PMC Article
Green DM, D'Angio GJ, Beckwith JB, Breslow NE, Grundy PE, Ritchey ML, Thomas PR
CA Cancer J Clin 1996 Jan-Feb;46(1):46-63. doi: 10.3322/canjclin.46.1.46. PMID: 8548525

Diagnosis

Ranganathan S, Lopez-Terrada D, Alaggio R
Pediatr Dev Pathol 2020 Mar-Apr;23(2):79-95. Epub 2019 Sep 25 doi: 10.1177/1093526619875228. PMID: 31554479
Rao R, Honavar SG
Indian J Pediatr 2017 Dec;84(12):937-944. Epub 2017 Jun 16 doi: 10.1007/s12098-017-2395-0. PMID: 28620731
Dasgupta R, Fuchs J, Rodeberg D
Semin Pediatr Surg 2016 Oct;25(5):276-283. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.011. PMID: 27955730
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Rodriguez-Galindo C, Orbach DB, VanderVeen D
Pediatr Clin North Am 2015 Feb;62(1):201-23. doi: 10.1016/j.pcl.2014.09.014. PMID: 25435120

Therapy

Erdmann F, Frederiksen LE, Bonaventure A, Mader L, Hasle H, Robison LL, Winther JF
Cancer Epidemiol 2021 Apr;71(Pt B):101733. Epub 2020 May 24 doi: 10.1016/j.canep.2020.101733. PMID: 32461035
Towbin AJ, Meyers RL, Woodley H, Miyazaki O, Weldon CB, Morland B, Hiyama E, Czauderna P, Roebuck DJ, Tiao GM
Pediatr Radiol 2018 Apr;48(4):536-554. Epub 2018 Feb 9 doi: 10.1007/s00247-018-4078-z. PMID: 29427028
Rodríguez-Mansilla J, González-Sánchez B, Torres-Piles S, Martín JG, Jiménez-Palomares M, Bellino MN
Rev Lat Am Enfermagem 2017 Jun 8;25:e2903. doi: 10.1590/1518-8345.1774.2903. PMID: 28614430Free PMC Article
Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJ
Cochrane Database Syst Rev 2016 Mar 31;3(3):CD008796. doi: 10.1002/14651858.CD008796.pub3. PMID: 27030386Free PMC Article
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591

Prognosis

Miller KD, Fidler-Benaoudia M, Keegan TH, Hipp HS, Jemal A, Siegel RL
CA Cancer J Clin 2020 Nov;70(6):443-459. Epub 2020 Sep 17 doi: 10.3322/caac.21637. PMID: 32940362
Varol Fİ
J Gastrointest Cancer 2020 Dec;51(4):1169-1175. doi: 10.1007/s12029-020-00494-w. PMID: 32856229
Suh E, Stratton KL, Leisenring WM, Nathan PC, Ford JS, Freyer DR, McNeer JL, Stock W, Stovall M, Krull KR, Sklar CA, Neglia JP, Armstrong GT, Oeffinger KC, Robison LL, Henderson TO
Lancet Oncol 2020 Mar;21(3):421-435. Epub 2020 Feb 14 doi: 10.1016/S1470-2045(19)30800-9. PMID: 32066543Free PMC Article
Bhakta N, Force LM, Allemani C, Atun R, Bray F, Coleman MP, Steliarova-Foucher E, Frazier AL, Robison LL, Rodriguez-Galindo C, Fitzmaurice C
Lancet Oncol 2019 Jan;20(1):e42-e53. doi: 10.1016/S1470-2045(18)30761-7. PMID: 30614477
Deschler B, Lübbert M
Cancer 2006 Nov 1;107(9):2099-107. doi: 10.1002/cncr.22233. PMID: 17019734

Clinical prediction guides

Wintering A, Hecht A, Meyer J, Wong EB, Hübner J, Abelson S, Feldman K, Kennedy VE, Peretz CAC, French DL, Maguire JA, Jobaliya C, Vasquez MR, Desai S, Dulman R, Nemecek E, Haines H, Hammad M, El Haddad A, Kogan SC, Abdullaev Z, Chehab FF, Tasian SK, Smith CC, Loh ML, Stieglitz E
Haematologica 2024 Aug 1;109(8):2533-2541. doi: 10.3324/haematol.2023.283776. PMID: 38152053Free PMC Article
Jones CD, Ho W, Robertson BF, Gunn E, Morley S
Am J Dermatopathol 2018 Sep;40(9):631-641. doi: 10.1097/DAD.0000000000001118. PMID: 30119102
Waszak SM, Northcott PA, Buchhalter I, Robinson GW, Sutter C, Groebner S, Grund KB, Brugières L, Jones DTW, Pajtler KW, Morrissy AS, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin BR, Zhou X, Baciu C, Lawerenz C, Chan JA, Varlet P, Guerrini-Rousseau L, Fults DW, Grajkowska W, Hauser P, Jabado N, Ra YS, Zitterbart K, Shringarpure SS, De La Vega FM, Bustamante CD, Ng HK, Perry A, MacDonald TJ, Hernáiz Driever P, Bendel AE, Bowers DC, McCowage G, Chintagumpala MM, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Kjaerheim K, Monoranu CM, Archer TC, Duke E, Pomeroy SL, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova MV, Milde T, Kratz CP, Samuel D, Zhang J, Solomon DA, Marra M, Eils R, Bartram CR, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Malkin D, Gajjar A, Korbel JO, Pfister SM
Lancet Oncol 2018 Jun;19(6):785-798. Epub 2018 May 9 doi: 10.1016/S1470-2045(18)30242-0. PMID: 29753700Free PMC Article
Olsen ØE
Pediatr Radiol 2015 Jan;45(1):35-41. Epub 2015 Jan 1 doi: 10.1007/s00247-014-3148-0. PMID: 25552390Free PMC Article
Wimmer K, Kratz CP, Vasen HF, Caron O, Colas C, Entz-Werle N, Gerdes AM, Goldberg Y, Ilencikova D, Muleris M, Duval A, Lavoine N, Ruiz-Ponte C, Slavc I, Burkhardt B, Brugieres L; EU-Consortium Care for CMMRD (C4CMMRD)
J Med Genet 2014 Jun;51(6):355-65. Epub 2014 Apr 15 doi: 10.1136/jmedgenet-2014-102284. PMID: 24737826

Recent systematic reviews

Kintossou AK, Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Kozlakidis Z, Huybrechts I
Nutrients 2023 Aug 29;15(17) doi: 10.3390/nu15173775. PMID: 37686807Free PMC Article
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Büttner-Teleagă A, Kim YT, Osel T, Richter K
Int J Environ Res Public Health 2021 Nov 7;18(21) doi: 10.3390/ijerph182111696. PMID: 34770209Free PMC Article
Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ
Arch Dis Child 2016 Oct;101(10):894-901. doi: 10.1136/archdischild-2016-311251. PMID: 27647842
Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJ
Cochrane Database Syst Rev 2016 Mar 31;3(3):CD008796. doi: 10.1002/14651858.CD008796.pub3. PMID: 27030386Free PMC Article

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    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

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